3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

@article{Hazen19973ChlorotyrosineAS,
  title={3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.},
  author={S. Hazen and J. Heinecke},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 9},
  pages={
          2075-81
        }
}
  • S. Hazen, J. Heinecke
  • Published 1997
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • Oxidation of LDL may be of pivotal importance in atherogenesis, but the mechanisms that promote oxidation in vivo remain poorly understood. We have explored the possibility that one pathway involves myeloperoxidase, a heme protein secreted by phagocytes. Myeloperoxidase is the only human enzyme known to generate hypochlorous acid (HOCl), a potent oxidizing agent, at physiological halide concentrations. LDL exposed to the complete myeloperoxidase-H2O2-Cl- system underwent chlorination of its… CONTINUE READING
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