3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

@article{Hazen19973ChlorotyrosineAS,
  title={3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.},
  author={Stanley L. Hazen and Jay W. Heinecke},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 9},
  pages={
          2075-81
        }
}
Oxidation of LDL may be of pivotal importance in atherogenesis, but the mechanisms that promote oxidation in vivo remain poorly understood. We have explored the possibility that one pathway involves myeloperoxidase, a heme protein secreted by phagocytes. Myeloperoxidase is the only human enzyme known to generate hypochlorous acid (HOCl), a potent oxidizing agent, at physiological halide concentrations. LDL exposed to the complete myeloperoxidase-H2O2-Cl- system underwent chlorination of its… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 252 CITATIONS, ESTIMATED 49% COVERAGE

Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.

  • Journal of immunology
  • 2006
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Oxysterols: modulators of cholesterol metabolism and other processes.

  • Physiological reviews
  • 2000
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1997
2019

CITATION STATISTICS

  • 12 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES