3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity.

@article{Yogeeswari20043Chloro2methylphenylsubstituted,
  title={3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity.},
  author={Perumal Yogeeswari and Rathinasabapathy Thirumurugan and Ramkumar Kavya and Jayakar Selwyn Samuel and James Stables and Dharmarajan Sriram},
  journal={European journal of medicinal chemistry},
  year={2004},
  volume={39 8},
  pages={729-34}
}
A series of 3-chloro-2-methylphenyl substituted semicarbazones (3-33) was synthesized and evaluated for anticonvulsant and CNS activities. After intraperitoneal injection to mice or rats, the semicarbazone derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and subcutaneous strychnine (scSTY)-induced seizure and neurotoxicity screens. The aryl urea (1) and the semicarbazide (2) showed anticonvulsant activity in the MES and scPTZ screens… CONTINUE READING
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