3-Chloro,4-methoxyfendiline is a potent GABA(B) receptor potentiator in rat neocortical slices.

@article{Ong20053Chloro4methoxyfendilineIA,
  title={3-Chloro,4-methoxyfendiline is a potent GABA(B) receptor potentiator in rat neocortical slices.},
  author={J. Ong and D. A. Parker and V. Marino and D. Kerr and N. M. Puspawati and R. Prager},
  journal={European journal of pharmacology},
  year={2005},
  volume={507 1-3},
  pages={
          35-42
        }
}
Using grease-gap recording from rat neocortical slices, the GABA(B) receptor agonist baclofen elicited reversible and concentration-dependent hyperpolarizing responses (EC50=18+/-2.3 microM). The hyperpolarizations were antagonised by the GABA(B) receptor antagonist Sch 50911 [(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid). (+)-N-1-(3-chloro-4-methoxyphenyl)ethyl-3,3-diphenylpropylamine (3-chloro,4-methoxyfendiline; 3-Cl,4-MeO-fendiline) reversibly potentiated baclofen-induced hyperpolarizing… Expand
Pharmacological actions of oximino‐propofol analogues at GABAB autoreceptors
Clinical potential of GABAB receptor modulators.
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