3-Acetylpyridine neurotoxicity to the nigrostriatal dopamine system in mice.

@article{Takada19933AcetylpyridineNT,
  title={3-Acetylpyridine neurotoxicity to the nigrostriatal dopamine system in mice.},
  author={Masahiko Takada and Toru Kono},
  journal={Neuroscience letters},
  year={1993},
  volume={161 2},
  pages={211-4}
}
Employing tyrosine hydroxylase (TH) immunohistochemistry, the neurotoxic effects of 3-acetylpyridine (3-AP), a potent neurotoxin selective to olivocerebellar climbing fibers, on the mesencephalic dopamine systems were investigated in mice. Systemic injections of 3-AP resulted in a large loss of TH-immunoreactive nigrostriatal neurons. On the other hand, 3… CONTINUE READING