3,4-Diaminopyridine-induced noradrenaline release from CNS tissue as a model for action potential-evoked transmitter release: effects of phorbol ester.

Abstract

We used rabbit hippocampus slices preincubated with [3H]noradrenaline (NA) and applied short pulses of 3,4-diaminopyridine (3,4-DAP) during superfusion to investigate the mechanism underlying the 3H overflow evoked by 3,4-DAP and the effects of the protein kinase C (PKC) activator, 4 beta-phorbol 12,13-dibutyrate (PDB), in this model. The 3H overflow evoked… (More)

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@article{Huang198934DiaminopyridineinducedNR, title={3,4-Diaminopyridine-induced noradrenaline release from CNS tissue as a model for action potential-evoked transmitter release: effects of phorbol ester.}, author={Henry Y. H. Huang and Georg Hertting and Clemens Allgaier and Rolf Jackisch}, journal={European journal of pharmacology}, year={1989}, volume={169 1}, pages={115-23} }