3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.

@article{Frey19863Trifluoromethyl3m125Iiodophenyldiazi,
  title={3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.},
  author={A. Frey and G. Kreibich and A. Wadhera and L. Clarke and D. Waxman},
  journal={Biochemistry},
  year={1986},
  volume={25 17},
  pages={
          4797-803
        }
}
  • A. Frey, G. Kreibich, +2 authors D. Waxman
  • Published 1986
  • Chemistry, Medicine
  • Biochemistry
  • Hepatic microsomes isolated from untreated male rats or from rats pretreated with phenobarbital (PB) or 3-methylcholanthrene (3-MC) were labeled with the hydrophobic, photoactivated reagent 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID). [125I]TID incorporation into 3-MC- and PB-induced liver microsomal protein was enhanced 5- and 8-fold, respectively, relative to the incorporation of [125I]TID into uninduced liver microsomes. The major hepatic microsomal cytochrome P-450 forms… CONTINUE READING
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