3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.

  title={3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.},
  author={F. Gentili and N. Pizzinat and C. Ordener and S. Marchal-Victorion and A. Maurel and R. Hofmann and P. Renard and P. Delagrange and M. Pigini and A. Parini and M. Giannella},
  journal={Journal of medicinal chemistry},
  volume={49 18},
  • F. Gentili, N. Pizzinat, +8 authors M. Giannella
  • Published 2006
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • On the basis of the observation that the central side effects of MAO inhibitors may represent a major limit for their use in pathological processes involving peripheral MAOs, we investigated the possibility of generating novel inhibitors able to target specifically peripheral MAOs. To address this issue, we designed compounds 7-28. From biological results, the 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole (Furaline, 17) proved to be a suitable lead. In fact, in enzyme assays on homogenate… CONTINUE READING
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