3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.

  title={3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.},
  author={Robert E Sammelson and Teng Ma and Luis J. V. Galietta and Alan S. Verkman and Mark J Kurth},
  journal={Bioorganic & medicinal chemistry letters},
  volume={13 15},
A novel class of activators for chloride conductance in the cystic fibrosis transmembrane conductance regulator (CFTR) protein has been identified. These 3-(2-benzyloxyphenyl)isoxazoles and 3-(2-benzyloxyphenyl)isoxazolines were synthesized employing the 1,3-dipolar cycloaddition of nitrile oxides with various alkene and alkyne dipolarophiles. Utilizing a fluorescence cell-based assay of halide transport, the best compounds increased CFTR-dependent chloride transport with half-maximal… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

CFTR pharmacology

Cellular and Molecular Life Sciences • 2016

Pharmacological therapy for cystic fibrosis: from bench to bedside.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…