3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.

@article{Boudinot19903Azido23dideoxyuridineC,
  title={3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.},
  author={F. Douglas Boudinot and Raymond F Schinazi and James M. Gallo and H. M. Mcclure and DavidC. Anderson and Kokila J. Doshi and P C Kambhampathi and Chung K Chu},
  journal={AIDS research and human retroviruses},
  year={1990},
  volume={6 2},
  pages={
          219-28
        }
}
The pharmacokinetics of the anti-human immunodeficiency virus type 1 nucleosides, 3'-azido-2',3'-dideoxyuridine (AzddU) and 3'-azido-3'-deoxythymidine (AZT) were characterized in rhesus monkeys. Half-life, total clearance, and steady-state volume of distribution were similar for both compounds. The observed pharmacokinetic parameters for AZT were comparable to those previously reported in humans. Oral absorption of AzddU and AZT was virtually complete after 60 mg/kg. However, bioavailability of… CONTINUE READING

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