3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection.

Abstract

3',5'-Cyclic diguanylic acid (cdiGMP) is emerging as a universal bacterial second messenger in regulating bacterial growth on surfaces. It has been recently shown that cdiGMP stimulates innate immunity and enhances antigen-specific humoral and cellular immune responses. We herein report that intranasal (i.n.) administration with cdiGMP induces an acute but… (More)
DOI: 10.1016/j.bbrc.2009.07.061

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