3′ Non-coding region sequences in eukaryotic messenger RNA

@article{Proudfoot19763NR,
  title={3′ Non-coding region sequences in eukaryotic messenger RNA},
  author={Nicholas Proudfoot and George G. Brownlee},
  journal={Nature},
  year={1976},
  volume={263},
  pages={211-214}
}
The sequence A–A–U–A–A–A is present in six different purified messenger RNA molecules (specifically the α- and β-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRN A of mouse (MOPC 21) and the ovalbumin mRN A of chicken) about 20 residues away from the 3′-terminal poly(A) sequence. In addition, a large selection of the 3′ non-coding regions of rabbit and human globin mRN As (both the α- and β- globin mRN As) are 85% homologous, demonstrating that this region is significantly… CONTINUE READING

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