3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications.

  title={3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications.},
  author={Danzhu Wang and Weixuan Chen and Yueqin Zheng and Chaofeng Dai and Ke Wang and Bowen Ke and Binghe Wang},
  journal={Organic & biomolecular chemistry},
  volume={12 23},
Cycloaddition reactions involving tetrazines have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate. By varying the substituents on tetrazines, cycloaddition rate variations of over 200 fold have been achieved with the… CONTINUE READING