3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.

@article{Das201335bisbenzylidene4piperidonesAR,
  title={3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.},
  author={Umashankar Das and Ravi Shankar Singh and Jane Alcorn and Mark Hickman and Richard J. Sciotti and Susan E. Leed and Patricia J. Lee and Norma Roncal and Jonathan R. Dimmock},
  journal={Bioorganic & medicinal chemistry},
  year={2013},
  volume={21 23},
  pages={7250-6}
}
Drug resistance is a major challenge in antimalarial chemotherapy. In addition, a complete cure of malaria requires intervention at various stages in the development of the parasite within the host. There are only a few antimalarials that target the liver stage of the Plasmodium species which is an essential part of the life cycle of the malarial parasite… CONTINUE READING