3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands


Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have antiproliferative and anti-inflammatory properties. With 57 distinct bromodomains… (More)
DOI: 10.1021/jm200640v

6 Figures and Tables


  • Presentations referencing similar topics