3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.

@article{Wu201535DiarylpyrazoleDO,
  title={3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.},
  author={Taizong Wu and Cheng Jiang and Ling Wang and Susan Lynne Morris-Natschke and Hui Miao and Lian-Quan Gu and Jun Xu and Kuo-Hsiung Lee and Qiong Gu},
  journal={Journal of natural products},
  year={2015},
  volume={78 7},
  pages={1593-9}
}
Four new 3,5-diarylpyrazole analogues (1-4) were isolated from an extract of the flowers of Chrysanthemun indicum using a combination of ammonolysis of the total flavonoid extract and an Aβ aggregation inhibitory activity guided purification procedure. All four compounds (1-4) showed moderate to potent activity against Aβ aggregation with EC50 values of 4.3, 15.8, 1.3, and 2.9 μM, respectively. Moreover, compound 3 showed low cytotoxicity and significant neuroprotective activity against A… CONTINUE READING
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