3,5‐Diiodo‐L‐thyronine powerfully reduces adiposity in rats by increasing the burning of fats

@article{Lanni200535DiiodoLthyroninePR,
  title={3,5‐Diiodo‐L‐thyronine powerfully reduces adiposity in rats by increasing the burning of fats},
  author={Antonia Lanni and Maria Moreno and Assunta Lombardi and Pieter de Lange and Elena Silvestri and Maurizio Ragni and Paola Farina and Gabriella Chieffi Baccari and Pupah Fallahi and Alessandro Antonelli and Fernando Goglia},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
The effect of thyroid hormones on metabolism has long supported their potential as drugs to stimulate fat reduction, but the concomitant induction of a thyrotoxic state has greatly limited their use. Recent evidence suggests that 3,5‐diiodo‐L‐thyronine (T2), a naturally occurring iodothyronine, stimulates metabolic rate via mechanisms involving the mitochondrial apparatus. We examined whether this effect would result in reduced energy storage. Here, we show that T2 administration to rats… 

3,5 Diiodo-l-Thyronine (T2) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality

The results indicate that, among others, the browning may be another cellular/molecular mechanism by which T2 exerts its beneficial effects of contrast to overweight and of reduction of fat mass in rats subjected to HFD.

Effects of 3,5-Diiodo-L-Thyronine Administration on the Liver of High Fat Diet-Fed Rats

The results show that in the liver of HFD rats, T2 prevents both lipid accumulation and oxidative stress associated with increased fat metabolism, and shows that HFD induces liver lipid peroxidation and stimulates the activity of enzymes involved in hydrogen peroxide metabolism, catalase in particular.

3,5-Diiodo-L-Thyronine (T2) Administration Affects Visceral Adipose Tissue Inflammatory State in Rats Receiving Long-Lasting High-Fat Diet

T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation, and Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.

Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats

T2, by activating SIRT1, triggers a cascade of events resulting in improvement of the serum lipid profile, prevention of fat accumulation, and, finally, Prevention of diet-induced insulin resistance in rats.

3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet

The prevention of VAT mass-gain by 3,5-T2 occurred through different molecular pathways that, together with the previously reported stimulation of resting metabolism and liver fatty acid oxidation, are associated with an anti adipogenic/lipogenic potential and positively impact on tissue health.

3,5‐Diiodo‐L‐thyronine prevents high‐fat‐diet‐induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations

  • M. MorenoE. Silvestri F. Goglia
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2011
3,5‐Diiodo‐L‐thyronine prevents high‐fat diet‐induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations and highlights T2 as a potential therapeutic approach to the treatment of diet‐ induced metabolic dysfunctions.

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats

In Sprague Dawley rats fed an unsaturated fat diet, T2 administration failed to improve NAFLD or whole body insulin sensitivity, and there was a modest improvement in hepatic insulin signaling, but this was not associated with significant differences in hepatics insulin action.

Metabolic effects of 3,5-Diiodo-L-Thyronine

It can be hypothesized that T2, by acting mainly on mitochondrial function and oxidative stress, might be able to prevent and revert the tissue damages and hepatic steatosis induced by a hyperlipidic diet and a concomitant reduction in the circulating levels LDL and triglycerides as well.

Effects of 3,5-diiodo-L-thyronine on the liver of high fat diet fed rats

Data show that multiple administrations of high doses of T2 to rats fed diets rich in lipid inhibit TSH secretion and prevent the onset of liver steatosis in these animals.
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