3,5,3'-Triiodothyronine receptors and thyroxine 5'-monodeiodinating activity in thyroid hormone-insensitive amphibia.

Abstract

Adult anuran Amphibia and neotenous urodeles, such as Necturus maculosus, rarely respond to thyroid hormone (TH). In this study, the possibility was examined that this lack of response is due either to an inability to convert thyroxine (T4) to 3,5,3'-triiodothyronine (T3) or to the absence of nuclear TH receptors. Following injection of [125I]T4… (More)

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