3,5,3'-Triiodothyronine deprivation affects phenotype and intracellular [Ca2+]i of human cardiomyocytes in culture.

@article{Forini2001353TriiodothyronineDA,
  title={3,5,3'-Triiodothyronine deprivation affects phenotype and intracellular [Ca2+]i of human cardiomyocytes in culture.},
  author={Francesca Forini and Aldo Paolicchi and Tommaso Pizzorusso and Gian Michele Ratto and Michela Saviozzi and Valentina Vanini and Giorgio Iervasi},
  journal={Cardiovascular research},
  year={2001},
  volume={51 2},
  pages={322-30}
}
OBJECTIVE A decrease in plasma T3 concentration is a frequent finding in patients with heart failure. However, the role of this 'low T3 syndrome' on disease evolution has never been clarified. As phenotypic and functional cardiomyocyte impairments are alterations that correlate with the failing myocardium, we studied the long-term effects of T3 deprivation on human cardiomyocyte structure and calcium handling. METHODS Atrial cardiomyocytes and myocardial tissue were cultured with or without 3… CONTINUE READING

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