3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

@article{Setola200334methylenedioxymethamphetamine,
  title={3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.},
  author={V. Setola and S. Hufeisen and K. J. Grande-Allen and I. Vesely and R. Glennon and B. Blough and R. Rothman and B. Roth},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 6},
  pages={
          1223-9
        }
}
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia [valvular heart disease (VHD)] and primary pulmonary hypertension observed in patients taking the now-banned appetite suppressant fenfluramine (Pondimin, Redux). Via large-scale, random screening of a portion of the receptorome, we have discovered that the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its N-demethylated metabolite 3,4… Expand
Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro
3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA).
Cardiovascular toxicity of novel psychoactive drugs: Lessons from the past
  • P. Dawson, J. Moffatt
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2012
Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(−)-MDMA Trained Mice
Effects of the Psychedelic Amphetamine MDA (3,4-Methylenedioxyamphetamine) in Healthy Volunteers
Endocrine and Neurochemical Effects of 3,4-Methylenedioxymethamphetamine and Its Stereoisomers in Rhesus Monkeys
L-Tyrosine Contributes to (+)-3,4-Methylenedioxymethamphetamine-Induced Serotonin Depletions
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.
Therapeutic and adverse actions of serotonin transporter substrates.
Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.
Serotonin 2B receptor is required for heart development.
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
  • B. Roth, K. Baner, +5 authors R. Rothman
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
...
1
2
3
...