3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

@article{Setola200334methylenedioxymethamphetamine,
  title={3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.},
  author={Vincent Setola and Sandra J. Hufeisen and K. Jane Grande-Allen and Ivan Vesely and Richard A Glennon and Bruce Blough and Richard B. Rothman and Bryan L. Roth},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 6},
  pages={
          1223-9
        }
}
  • Vincent Setola, Sandra J. Hufeisen, +5 authors Bryan L. Roth
  • Published 2003
  • Biology, Medicine
  • Molecular pharmacology
  • Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia [valvular heart disease (VHD)] and primary pulmonary hypertension observed in patients taking the now-banned appetite suppressant fenfluramine (Pondimin, Redux). Via large-scale, random screening of a portion of the receptorome, we have discovered that the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its N-demethylated metabolite 3,4… CONTINUE READING

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    References

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    Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.

    VIEW 1 EXCERPT

    Serotonin 2B receptor is required for heart development.

    VIEW 2 EXCERPTS