3,4-methylenedioxymethamphetamine ("Ecstasy") stimulates the expression of alpha1(I) procollagen mRNA in hepatic stellate cells.

@article{VarelaRey199934methylenedioxymethamphetamineS,
  title={3,4-methylenedioxymethamphetamine ("Ecstasy") stimulates the expression of alpha1(I) procollagen mRNA in hepatic stellate cells.},
  author={Marta Varela-Rey and Cristina Montiel-Duarte and Guadalupe Beitia and Edurne Cenarruzabeitia and Mar{\'i}a J. Iraburu},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={259 3},
  pages={678-82}
}
3,4-Methylenedioxymethamphetamine, MDMA ("Ecstasy"), has been previously shown to produce cell necrosis and fibrosis in the liver. Our aim was to study the effect of MDMA on the type I collagen production by a cell line of hepatic stellate cells (HSC), the cell type mainly responsible for collagen synthesis in the liver. We demonstrated that MDMA increases alpha1(I) procollagen mRNA levels and that this increase correlates with glutathione depletion and enhanced hydrogen peroxide production by… CONTINUE READING

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