3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions

@article{Valente201534MethylenedioxypyrovaleroneI,
  title={3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions},
  author={Maria Jo{\~a}o Valente and Ana Margarida Ara{\'u}jo and Renata Silva and Maria de Lourdes Bastos and F{\'e}lix Carvalho and Paula Guedes de Pinho and M{\'a}rcia Carvalho},
  journal={Archives of Toxicology},
  year={2015},
  volume={90},
  pages={1959-1973}
}
Synthetic cathinones have emerged in recreational drug markets as legal alternatives for classical amphetamines. Though currently banned in several countries, 3,4-methylenedioxypyrovalerone (MDPV) is one of the most commonly abused cathinone derivatives worldwide. We have recently reported the potential of MDPV to induce hepatocellular damage, but the underlying mechanisms responsible for such toxicity remain to be elucidated. Similar to amphetamines, a prominent toxic effect of acute… CONTINUE READING
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