3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors

@article{Rusyniak200734MethylenedioxymethamphetamineA8,
  title={3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors},
  author={Daniel E. Rusyniak and Maria V. Zaretskaia and Dmitry V. Zaretsky and Joseph A. Dimicco},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={323},
  pages={477 - 487}
}
The popular drug of abuse 3,4-methylenedioxymethamphetamine (MDMA) has complex interactions with thermoregulatory systems, resulting in either hyperthermia or hypothermia. MDMA induces hypothermia when given to animals housed at a low ambient temperature. In this study we report that MDMA (7.5 mg/kg i.p.) given at normal ambient temperatures of 24 to 25°C caused, in conscious freely moving rats, hypothermia (mean decrease from baseline of 1.1 ± 0.06°C at 40 min). Pretreating animals with a 0.5… 

Figures from this paper

Neuroadaptive Changes in  5-HT1A Autoreceptor Sensitivity  Following High-Dose MDMA Treatment

TLDR
The results do not indicate an increase in sensitivity of the 5-HT1A autoreceptor, and hence the original hypothesis is not supported, and there were a number of methodological issues, as indicated by the lack of MDMAinduced 5-HT deficits, which prevent a firm conclusion from being drawn.

Effect of Ambient Temperature on the Thermoregulatory and Locomotor Stimulant Effects of 4-Methylmethcathinone in Wistar and Sprague-Dawley Rats

TLDR
Results show that the cathinone analog 4-MMC exhibits thermoregulatory and locomotor properties that are distinct from those established for methamphetamine or MDMA in prior work, despite recent evidence of neuropharmacological similarity with MDMA.

Tolerance to the Behavioural and Neurochemical Effects of MDMA Following Repeated Exposure

TLDR
MDMA produced dose-dependent hyperactivity and tolerance was produced by MDMA pretreatment and rats were tolerant to the effects of MDMA and m-CPP two weeks following MDMA Pretreatment.

Yohimbine is a 5-HT 1 A agonist in rats in doses exceeding 1 mg / kg

TLDR
It is confirmed that yohimbine possesses 5-HT1A properties, and demonstrated that in doses above 1 mg/kg significantly activate these receptors.

Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg/kg.

5-Hydroxytryptamine inhibits neuronal high-voltage-activated calcium currents in the preoptic anterior hypothalamus via 5-hydroxytryptamine 1 A and 7 receptors

TLDR
5-HT1A and 5-HT7 receptors were suggested to be involved in the 5- HT-induced decrease of HVA calcium currents in PO/AH neurons and might contribute to the hypothermic effects of thermoregulation.

8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius.

TLDR
It is concluded that the vagal-mediated apneic response to MOR activation depends on PCFs, which is fully antagonized by systemic 8-OH-DPAT challenge largely via acting on mNTS 5HT(1A)Rs.

References

SHOWING 1-10 OF 67 REFERENCES

Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors.

TLDR
A role for 5-HT(1B/1D) in mediating the acute hyperactivity evoked by (+)- MDMA is supported, and the development of sensitization to (+)-MDMA was associated with supersensitivity to a 5- HT(1 B/1A) agonist, suggesting that these receptors may contribute to sensitization.

The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

TLDR
It is concluded that 8-OH-DPAT probably produces its hypothermic effects by actions at 5-HT receptors located presynaptically on5-HT neurones, while the stereotyped components of the serotonin syndrome appear to be mediated by post-synaptic receptors.

Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) in rats

TLDR
A stress-free, biotelemetric monitoring technique was used to investigate the effects of ambient temperature on the hyperthermic and hyperkinetic effects of 3,4-methylenedioxymethamphetamine and the implications for the understanding of the thermotoxic effects of MDMA in human drug users are discussed.

The acute cardiovascular effects of 3,4‐methylenedioxymethamphetamine (MDMA) and p‐methoxyamphetamine (PMA)

TLDR
Data indicate that although these drugs are considered similar in their psychotrophic effects they have different actions on the cardiovascular system of the rat, which may have implications in the diagnosis and emergency treatment of victims of MDMA/PMA toxicity.
...