3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective interactions at brain 5-HT1 and 5-HT2 receptors

  title={3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective interactions at brain 5-HT1 and 5-HT2 receptors},
  author={R. Lyon and R. Glennon and M. Titeler},
  • R. Lyon, R. Glennon, M. Titeler
  • Published 2004
  • Chemistry, Medicine
  • Psychopharmacology
  • Abstract3,4-Methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), and their optical isomers, were assayed for their affinities at radiolabeled brain serotonin (5-HT1, 5-HT2) and dopamine (D2) binding sites. (R(−)-MDA and R(−)-MDMA) displayed moderate affinities for 3H-ketanserin-labeled 5-HT2 sites (Ki=3425 and 3310 nM, respectively) whereas the affinities for their S(+)-enantiomers were lower (Ki=13,000 and 15,800 nM, respectively). Similar absolute and relative… CONTINUE READING
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