3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine

@article{Mckenna199134MethylenedioxyamphetamineA,
  title={3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine},
  author={D. Mckenna and X. Guan and A. Shulgin},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={38},
  pages={505-512}
}
The effect of various analogues of the neurotoxic amphetamine derivative, MDA (3,4-methylenedioxyamphetamine) on carrier-mediated, calcium-independent release of 3H-5-HT and 3H-DA from rat brain synaptosomes was investigated. Both enantiomers of the neurotoxic analogues MDA and MDMA (3,4-methylenedioxymethamphetamine) induce synaptosomal release of 3H-5-HT and 3H-DA in vitro. The release of 3H-5-HT induced by MDMA is partially blocked by 10(-6) M fluoxetine. The (+) enantiomers of both MDA and… Expand
87 Citations
Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity
Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the wistar rat
Interactions of methylenedioxymethamphetamine with monoamine transmitter release mechanisms in rat brain slices
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices.
A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives.
Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes.
Acute administration of methylenedioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs.
  • C. Schmidt
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1987
Ring-substituted amphetamine interactions with neurotransmitter receptor binding sites in human cortex
Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline.
Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.
Antagonism of 5-hydroxytryptamine2 receptor-mediated phosphatidylinositol turnover by d-lysergic acid diethylamide.
  • P. Pierce, S. Peroutka
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1988
...
1
2
3
4
5
...