3,4,3-(LI-1,2-HOPO): An alternative chelator for 89Zr radiopharmaceuticals

  title={3,4,3-(LI-1,2-HOPO): An alternative chelator for 89Zr radiopharmaceuticals},
  author={Melissa A Deri and Shashikanth Ponnala and Brian M. Zeglis and G{\'a}bor Pohl and J. J. Dannenberg and Jason S. Lewis and Lynn C. Francesconi},
  journal={Nuclear Medicine and Biology},
5 Citations

The chemistry of PET imaging with zirconium-89.

The primary focus is on coordination chemistry but other aspects such as isotope production, isotope properties, handling and radiochemical techniques and characterisation of cold and labelled complexes are included.

Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

It is shown that FSC is a suitable alternative to DFO for radiolabeling of biomolecules with zirconium-89 and that 89Zr-radiolabeled of DFO conjugates at higher temperature reduces off-chelate binding leading to significantly improved tumor-to-organ ratios and therefore enhancing image contrast.

Multifunctional Desferrichrome Analogues as Versatile 89Zr(IV) Chelators for ImmunoPET Probe Development.

New bifunctional hexa- and octadentate analogues of the hydroxamate-containing siderophore desferrichrome (DFC) have been synthesized and evaluated as 89Zr-chelating agents for immunoPET applications and are suitable for the mild and inert radiolabeling of antibodies with the radionuclide 89 Zr.

Title Engineered recognition of tetravalent zirconium and thorium by chelator-protein systems : Toward flexible radiotherapy and imaging platforms Permalink

A new chelating platform composed of a multidentate high-affinity oxygen-donating ligand 3,4,3-LI(CAM) bound to the mammalian protein siderocalin is demonstrated, revealing this ligand to be one of the most powerful chelators for both trivalent and tetravalent metal ions at physiological pH.