3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus.

@article{Agrawal19813434TetrachlorobiphenylGT,
  title={3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus.},
  author={Ashok Kumar Agrawal and Hugh A. Tilson and Stephen C Bondy},
  journal={Toxicology letters},
  year={1981},
  volume={7 6},
  pages={417-24}
}
Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the corpus striatum. Mice exposed to TCB in utero had elevated levels of motor activity, which were associated with decreased DA levels and DA receptor binding sites. The results… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Friedhoff, Enduring changes in dopamine receptor cells of pups from drug

  • A.J.H. Rosengarten
  • specificity, Psychopharmacology,
  • 1978

Transplacental toxicology of the polychlorinated and polybrominated biphenyls, in D.D

  • G. W. Lucier, G. J. Davis, J .A. McLachlan
  • Mahlum et al. (Eds.), Hanford Symposium on…
  • 1978

Simultaneous Statistical Inference, McGraw-Hill, New York, 1972

  • J. Dankova, P. Bedard, P. Langelier, L. Poirier
  • J. Pharm. Sci.,
  • 1966

Similar Papers

Loading similar papers…