3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease.

@article{Tadi200533DiindolylmethaneAC,
  title={3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease.},
  author={Kiranmayi Tadi and Yushan Chang and Badithe T. Ashok and Yuangen Chen and Augustine L. Moscatello and Steven Schaefer and Stimsom P Schantz and A. J. Policastro and Jan Geliebter and Raj K. Tiwari},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={337 3},
  pages={1019-25}
}
Considerable epidemiological evidence exists to link thyroid disease with differing patterns of dietary consumption, in particular, cruciferous vegetables. We have been studying the anti-thyroid cancer (TCa) activity of indole-3-carbinol (I3C) found in cruciferous vegetables and its acid catalyzed dimer, 3,3'-diindolylmethane (DIM). There are no studies as yet to elucidate the effect of these compounds on the altered proliferative patterns in goiter or thyroid neoplasia. In this study, we… CONTINUE READING