3,3'-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages.

@article{Cho200833DiindolylmethaneST,
  title={3,3'-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages.},
  author={H. J. Cho and Mi Ra Seon and Yeo Myeong Lee and Jaebong Kim and Jin-Kyung Kim and Sang Geon Kim and Jung Han Yoon Park},
  journal={The Journal of nutrition},
  year={2008},
  volume={138 1},
  pages={17-23}
}
3,3'-Diindolylmethane (DIM), a major acid-condensation product of indole-3-carbinol, has been shown to have multiple anticancer effects in experimental models. Because recurrent or chronic inflammation has been implicated in the development of a variety of human cancers, this study examined the antiinflammatory effects of DIM and the underlying mechanisms using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. DIM significantly decreased the release of nitric oxide (NO… CONTINUE READING
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