3,3',4,4'-Tetrachlorobiphenyl. Excretion and tissue retention of hydroxylated metabolites in the mouse.

@article{Wehler19893344TetrachlorobiphenylEA,
  title={3,3',4,4'-Tetrachlorobiphenyl. Excretion and tissue retention of hydroxylated metabolites in the mouse.},
  author={E Klasson Wehler and Amber Bergman and I. Brandt and Per Ola Darnerud and Carl Axel Wachtmeister},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 4},
  pages={441-8}
}
The coplanar 3,3',4,4'-tetrachlorobiphenyl (TCB) was given orally to mice and the metabolite patterns in feces, urine, liver, and adipose tissue were examined. In feces, 80% of the dose was excreted within 5 days. 5-Hydroxy-, 6-hydroxy-TCB, 4-hydroxy-3,3',4',5-tetrachlorobiphenyl, and unmetabolized TCB were identified by comparison to synthetic standards (GC/MS). 4-Hydroxy-trichlorobiphenyl and a dihydroxy-trichlorobiphenyl were indicated by the fragmentation pattern of the corresponding… CONTINUE READING