3'CBFbeta deletion associated with inv(16) in acute myeloid leukemia.

  title={3'CBFbeta deletion associated with inv(16) in acute myeloid leukemia.},
  author={Johanna Kelly and Nicola J Foot and Eibhlin Conneally and Helen Enright and Mervyn W Humphreys and Karen Saunders and Michael J. Neat},
  journal={Cancer genetics and cytogenetics},
  volume={162 2},
Recent reports have shown that concomitant submicroscopic deletions can occur in association with chromosomal translocations/inversions in several leukemia subtypes. Detectable by fluorescence in situ hybridization (FISH), these losses of sequence include deletion of the 5' region of the ABL gene and the 3' region of BCR in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL), as well as the 5' region of ETO in acute myeloid leukemia (AML) French-American-British type M2… CONTINUE READING