3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression.

@article{Stauber19883PO,
  title={3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression.},
  author={Claudia Stauber and Daniel Sch{\"u}mperli},
  journal={Nucleic acids research},
  year={1988},
  volume={16 20},
  pages={9399-414}
}
A short histone-like fusion RNA, generated when the RNA 3' processing signal from a mouse histone H4 gene is inserted into a heterologous transcription unit, becomes correctly down-regulated in G1-arrested cells of a temperature-sensitive mouse mastocytoma cell cycle mutant (21-Tb; Stauber et al., EMBO J. 5, 3297-3303 [1986]), due to a specific deficiency in histone RNA processing (Lüscher and Schümperli, EMBO J. 6, 1721-1726 [1987]). In contrast, inhibitors of DNA synthesis, known to stimulate… CONTINUE READING

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