3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.

  title={3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.},
  author={Peter Storz and A. C. Toker},
  journal={Frontiers in bioscience : a journal and virtual library},
The recently discovered 3'-phosphoinositide-dependent kinase-1 (PDK-1) is a serine/threonine protein kinase which phosphorylates several members of the conserved AGC kinase superfamily (comprising the prototypes protein kinases A (PKA), G (PKG) and C (PKC)). Phosphorylation of a threonine or serine residue in the activation loop (also known as the T-loop) of these kinases is a critical step in their activation, and is typically accompanied by additional phosphorylations elsewhere in the… CONTINUE READING


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