3'-nucleotidase/nuclease activity allows Leishmania parasites to escape killing by neutrophil extracellular traps.

@article{GuimaresCosta20143nucleotidasenucleaseAA,
  title={3'-nucleotidase/nuclease activity allows Leishmania parasites to escape killing by neutrophil extracellular traps.},
  author={Anderson B. Guimar{\~a}es-Costa and Thiago S. DeSouza-Vieira and Rafael Paletta-Silva and Anita Leoc{\'a}dio Freitas-Mesquita and Jos{\'e} Roberto Meyer-Fernandes and Elvira Maria Breier Saraiva},
  journal={Infection and immunity},
  year={2014},
  volume={82 4},
  pages={1732-40}
}
Leishmaniasis is a widespread neglected tropical disease caused by parasites of the Leishmania genus. These parasites express the enzyme 3'-nucleotidase/nuclease (3'NT/NU), which has been described to be involved in parasite nutrition and infection. Bacteria that express nucleases escape the toxic effects of neutrophil extracellular traps (NETs). Hence, we investigated the role of 3'NT/NU in Leishmania survival of NET-mediated killing. Promastigotes of Leishmania infantum were cultured in high… CONTINUE READING