3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).

@article{Barbier20003azido3deoxythimidineI,
  title={3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).},
  author={Olivier Barbier and David Turgeon and Caroline Girard and Melinda Green and Thomas R. Tephly and Dean W. Hum and Alain B{\'e}langer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 5},
  pages={497-502}
}
3'-Azido-3'-deoxythymidine (AZT) is frequently prescribed to patients infected with the human immunodeficiency virus. After absorption, AZT is rapidly metabolized into 3'-azido-3'-deoxy-5'-glucuronylthymidine by UDP-glucuronosyltransferase (UGT) enzymes. Using labeled [(14)C]UDP-glucuronic acid and microsomal preparations from human kidney 293 cells stably expressing the different human UGT2B isoenzymes, it was demonstrated that AZT glucuronidation is catalyzed specifically by human UGT2B7. The… CONTINUE READING
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