3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.

@article{Zanetti20123UTRAF,
  title={3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.},
  author={Krista A. Zanetti and Majda Haznadar and Judith A. Welsh and Ana I Robles and Br{\'i}d M Ryan and Andrew C. McClary and Elise D. Bowman and Julie E. Goodman and Toralf Bernig and Stephen J. Chanock and Curtis C. Harris},
  journal={Cancer research},
  year={2012},
  volume={72 6},
  pages={1467-77}
}
Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and corresponding haplotypes with colon cancer risk in a case-control study. Four SNPs in the 3'-untranslated region (UTR) of the gene (rs10082466, rs2120132, rs2099902, and… CONTINUE READING
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The role of mannose-binding lectin in health and disease

  • MW Turner
  • Mol.Immunol
  • 2003
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