3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition.

@article{Drees199335CyclicNP,
  title={3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition.},
  author={Markus Drees and Robert Zimmermann and Gerhard Eisenbrand},
  journal={Cancer research},
  year={1993},
  volume={53 13},
  pages={
          3058-61
        }
}
Isoenzymes of 3',5'-cyclic nucleotide phosphodiesterase (PDE) have been characterized in B16 murine melanoma cells and MCF-7 human mammary carcinoma cells. Separation of soluble phosphodiesterase activity by fast protein liquid chromatography on a Mono-Q column resolved three isoenzymes, MCF-7 cells contained a cyclic GMP-specific isoenzyme (PDE-V), a cyclic GMP-activable isoenzyme (PDE-II), and a cyclic AMP-specific isoenzyme (PDE-IV). B16 cells contained a cyclic GMP-specific isoenzyme (PDE-V… CONTINUE READING

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