2R or not 2R: Testing hypotheses of genome duplication in early vertebrates

@article{Hughes20032RON,
  title={2R or not 2R: Testing hypotheses of genome duplication in early vertebrates},
  author={Austin L. Hughes and Robert L Friedman},
  journal={Journal of Structural and Functional Genomics},
  year={2003},
  volume={3},
  pages={85-93}
}
The widely popular hypothesis that there were two rounds of genome duplication by polyploidization early in vertebrate history (the 2R hypothesis) has been difficult to test until recently. Among the lines of evidence adduced in support of this hypothesis are relative genome size, relative gene number, and the existence of genomic regions putatively duplicated during polyploidization. The availability of sequence for a substantial portion of the human genome makes possible the first rigorous… CONTINUE READING
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