2D and 3D MALDI-imaging: conceptual strategies for visualization and data mining.

@article{Thiele20142DA3,
  title={2D and 3D MALDI-imaging: conceptual strategies for visualization and data mining.},
  author={Herbert Thiele and Stefan Heldmann and Dennis Trede and Jan Strehlow and Stefan Wirtz and Wolfgang Dreher and Judith Berger and Janina Oetjen and Jan Hendrik Kobarg and Bernd Fischer and Peter Maass},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1844 1 Pt A},
  pages={117-37}
}
3D imaging has a significant impact on many challenges in life sciences, because biology is a 3-dimensional phenomenon. Current 3D imaging-technologies (various types MRI, PET, SPECT) are labeled, i.e. they trace the localization of a specific compound in the body. In contrast, 3D MALDI mass spectrometry-imaging (MALDI-MSI) is a label-free method imaging the spatial distribution of molecular compounds. It complements 3D imaging labeled methods, immunohistochemistry, and genetics-based methods… CONTINUE READING

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