Artesunic acid (ASH), an antimalarial drug, has low oral bioavailability due to its low aqueous solubility. To overcome this problem, artesunate (AS) was intercalated into zinc basic salt (ZBS) via co-precipitation. AS was immobilized with a tilted double layer arrangement, which was also confirmed by XRD and 1-D electron density mapping. In order to… (More)
Figure 6. (A) In-vitro dissolution profile of (a) intact ASH (&) (b) ZBS-AS (^) and (c) ZBS-AS-L100 (~) in pH 6.8 medium. Plots of kinetic equation of (B) a parabolic diffusion model, (C) Freundlich model for the release of AS from (a) ZBS-AS and (b) ZBS-AS-L100 in pH 6.8 medium.