2D, 3D-QSAR and docking studies of 1,2,3-thiadiazole thioacetanilides analogues as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

@inproceedings{Jain20122D3A,
  title={2D, 3D-QSAR and docking studies of 1,2,3-thiadiazole thioacetanilides analogues as potent HIV-1 non-nucleoside reverse transcriptase inhibitors},
  author={Shailesh V. Jain and Manjunath D. Ghate and Kamlendra Singh Bhadoriya and Sanjaykumar Baburao Bari and Amar J. Chaudhari and Jayshri S. Borse},
  booktitle={Organic and medicinal chemistry letters},
  year={2012}
}
UNLABELLED BACKGROUND The discovery of clinically relevant inhibitors of HIV-RT for antiviral therapy has proven to be a challenging task. To identify novel and potent HIV-RT inhibitors, the quantitative structure-activity relationship (QSAR) approach became very useful and largely widespread technique forligand-based drug design. METHODS We perform… CONTINUE READING