2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness.

@article{Chuang20002B4SO,
  title={2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness.},
  author={Samuel S. Chuang and Myoung Hee Kim and Lori A Johnson and Per Arne Albertsson and Richard P. Kitson and Ulf Nannmark and Ronald H. Goldfarb and Porunelloor A Mathew},
  journal={Immunology},
  year={2000},
  volume={100 3},
  pages={378-83}
}
2B4 is a surface molecule found on all human natural killer (NK) cells, a subset of CD8+ T cells, monocytes and basophils. It was originally identified on mouse NK cells and the subset of T cells that mediate non-major histocompatibility complex (MHC)-restricted killing. Recently,9 we have cloned the human homologue of 2B4 (h2B4) and found h2B4 to also mediate non-MHC-restricted cytotoxicity. In this study, we examine h2B4 in regulating various functions of NK cells using a human NK cell line… CONTINUE READING
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