2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA.

@article{Jurgens20062AproIA,
  title={2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA.},
  author={Christy K Jurgens and David J. Barton and Nidhi Krishan Sharma and B Joan Morasco and Sushma A Ogram and James Bert Flanegan},
  journal={Virology},
  year={2006},
  volume={345 2},
  pages={346-57}
}
Poliovirus 2A(pro) is required for the inhibition of host cell protein synthesis and efficient viral replication. We investigated the role of 2A(pro) in regulating viral RNA stability, translation and replication in HeLa S10 reactions. The protease activity of 2A(pro) or its polyprotein precursors, 2AB or P2, was required to increase the stability of viral RNA and prolong translation. Since other viral proteins were not required for the observed effects of 2A(pro), it is likely that a cellular… CONTINUE READING