2A and the Auxin-Based Degron System Facilitate Control of Protein Levels in Plasmodium falciparum

@inproceedings{Kreidenweiss20132AAT,
  title={2A and the Auxin-Based Degron System Facilitate Control of Protein Levels in Plasmodium falciparum},
  author={Andrea Kreidenweiss and Annika V. Hopkins and Benjamin Mordm{\"u}ller},
  booktitle={PloS one},
  year={2013}
}
Analysis of gene function in Plasmodium falciparum, the most important human malaria parasite, is restricted by the lack of robust and simple reverse genetic tools. Approaches to manipulate protein levels post-translationally are powerful tools to study protein-off effects especially in the haploid malaria parasite where genetic knockouts of essential genes are lethal. We investigated if the auxin-inducible degron system is functional in P. falciparum and found that degron-tagged yellow… CONTINUE READING
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