27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells.

  title={27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells.},
  author={Pamela Cruz and M. J. Epu{\~n}{\'a}n and M. Ram{\'i}rez and C. Torres and L. Valladares and W. Sierralta},
  journal={Oncology reports},
  volume={28 3},
  • Pamela Cruz, M. J. Epuñán, +3 authors W. Sierralta
  • Published 2012
  • Biology, Medicine
  • Oncology reports
  • The principal aim of this study was to analyze in estrogen receptor-positive MCF7 cells the response of three estrogen-dependent proteins to 27-hydroxycholesterol (27OHC), a major circulating cholesterol metabolite. Immunofluorescence, immunoblotting and immunogold labelling analyses of MCF7 cells exposed for up to 72 h to 2 nM estradiol (E2) or to 2 µM 27OHC demonstrated similar responses in the expression of MnSOD and ERβ compared to… CONTINUE READING
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