27 Poxvirus DNA Replication

  title={27 Poxvirus DNA Replication},
  author={Paula Traktman},
Poxviruses, of which vaccinia is the prototype, are complex DNA viruses that display an unusual degree of physical and genetic autonomy from the host cell. The vaccinia genome encodes most, if not all, of the functions required for three temporally regulated phases of transcription and for DNA replication (Moss 1990a,b, 1994; Traktman 1990a,b, 1991). In addition, the 192-kb genome encodes numerous proteins that interact with and modulate the inflammatory and immune responses of the host (Smith… CONTINUE READING