27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

  title={27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.},
  author={Erik R Nelson and Suzanne E. Wardell and Jeff S. Jasper and Sunghee Park and Sunil Suchindran and Matthew Keller Howe and Nicole J Carver and Ruchita V Pillai and Patrick M Sullivan and Varun Sondhi and Michihisa Umetani and Joseph Geradts and Donald P McDonnell},
  volume={342 6162},
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metastasis in mouse models of breast cancer. The effects of cholesterol on tumor pathology required its conversion to 27HC by the cytochrome P450 oxidase… CONTINUE READING
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