26-Week oral safety study in macaques for transgenic rice containing major human T-cell epitope peptides from Japanese cedar pollen allergens.

@article{Domon200926WeekOS,
  title={26-Week oral safety study in macaques for transgenic rice containing major human T-cell epitope peptides from Japanese cedar pollen allergens.},
  author={Eiji Domon and Hidenori Takagi and Sakiko Hirose and Koichi Sugita and Saori Kasahara and Hiroyasu Ebinuma and F. Takaiwa},
  journal={Journal of agricultural and food chemistry},
  year={2009},
  volume={57 12},
  pages={5633-8}
}
A study of repeated oral administration of transgenic rice containing a hybrid peptide of major human T-cell epitopes (7Crp) from Japanese cedar pollen allergens was carried out in cynomolgus macaques over 26 weeks. The monkeys were divided into three groups, each comprising three males and three females, administered a high dose of transgenic rice, a low dose of transgenic rice, or a high dose of the parental rice strain. The transgenic rice 7crp#10 and the parental nontransgenic control were… CONTINUE READING

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