25 years since the discovery of presynaptic receptors: present knowledge and future perspectives.

@article{Langer199725YS,
  title={25 years since the discovery of presynaptic receptors: present knowledge and future perspectives.},
  author={Salomon Z. Langer},
  journal={Trends in pharmacological sciences},
  year={1997},
  volume={18 3},
  pages={95-9}
}
The release of neurotransmitters is modulated through presynaptic autoreceptors that are acted upon by the neurone's own transmitter. The presynaptic inhibitory terminal autoreceptors were first described for noradrenergic neurones (alpha 2-adrenoceptors) and subsequently for other neurotransmitters: dopamine (D2/D3), acetylcholine (M2), GABA (GABAB), histamine (H3) and serotonin (5-HT10). This negative feedback loop introduces terminal regulation into the neural secretory event. Saloman Langer… CONTINUE READING

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