25 years of HNPCC.

  title={25 years of HNPCC.},
  author={Henry T. Lynch and Jane F. Lynch},
  journal={Anticancer research},
  volume={14 4B},
Research on the genetic, molecular genetic, clinical features, and natural history of HNPCC has shown tremendous progress and evolution during the past 25 years. Specifically, HNPCC's autosomal dominant mode of genetic transmission has now been documented through linkage studies of the gene at 2p (MSH2) and at 3p (MLH1) with the cloning of these genes. Also, the tumor spectrum has increased, which now, in addition to carcinoma of the colon, endometrium, stomach, and ovary, includes transitional… CONTINUE READING


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