25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds.

@article{Somjen200525hydroxyvitaminDI,
  title={25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds.},
  author={Dalia Somjen and Yosef Weisman and Fortune Kohen and Batya Gayer and Rona Limor and Orly Sharon and Niva Jaccard and Esther Knoll and Naftali Stern},
  journal={Circulation},
  year={2005},
  volume={111 13},
  pages={1666-71}
}
BACKGROUND 1,25(OH)2 vitamin D3 exerts multiple effects in human vascular smooth muscle cells (VSMCs). We therefore tested the possibility that VSMCs possess an endogenous 25-hydroxyvitamin D3-1alpha-hydroxylase system, the final enzyme in the biosynthetic pathway of 1,25(OH)2D3. METHODS AND RESULTS We assessed the expression and activity of 25-hydroxyvitamin D3-1alpha-hydroxylase by real-time polymerase chain reaction and the conversion of 25(OH)D3 into 1,25(OH)2D3. First, 25-hydroxyvitamin… CONTINUE READING

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